Saturday, March 3, 2012

Two methylase genes, hpyIIIM and hpyIM, are preceded by alternative genes.

2003 MAR 3 - (NewsRx.com & NewsRx.net) -- "A recently identified Helicobacter pylori gene, hrgA, was previously reported to be present in 70 (33%) of 208 strains examined," researchers in Japan report.

"Sequence analysis of nine such strains indicated that in each strain hrgA replaced hpyIIIR, which encodes a restriction endonuclease and which, together with the gene for its cognate methyltransferase, constitutes the hpyIII locus.

"As a consequence of either the hrgA insertion or independent mutations, hpyIIIM function was lost in 11 (5%) of the 208 strains examined, rendering chromosomal DNA sensitive to MboI digestion.

"The evolutionary history of …

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